HEMATOLOGIC MALIGNANCIES DEVELOPING IN SYRIAN GOLDEN-HAMSTERS DURING INDUCTION OF PANCREATIC-CARCINOMA

We report 30 hematologic malignancies arising in 25 of 236 Syrian gold en hamsters (SGH) that received combinations of N-nitrobis(2-oxopropyl )amine (BOP) and Streptozotocin (STZ), Lesions developed with morpholo gical similarity to human small lymphocytic (n = 7), diffuse mixed (It = 2), diffuse large cell lymphoma (n = 13), follicular lymphoma(n = 2 ), anaplastic large cell lymphoma (n = 3), hairy cell leukemia (n = 2) , malignant histiocytosis (n = 1) and discordant lymphomas (n = 5), Th e types and distribution of these lesions are different from epizootic lymphomas in SGH. We also report a higher percentage (12 versus 4.6%) and the earlier appearance (less than or equal to 40 versus 80-112 we eks) compared with aging-associated spontaneous SGH lymphoma, The feat ures of these hematologic malignancies have not been previously report ed in epizootic or aging-associated spontaneous lymphomas and therefor e suggest a new class of hematologic lesions in SGH, Benign and atypic al hyperplasia correlated with STZ administration (r = 0.97, P = 0.03) , The malignant lesions correlated with areas of lymphoid hyperplasia (r = 0.78, P = 0.004), Only one of the 21 untreated SGH spontaneously developed a low grade lymphoma, The unusual types, distribution and oc currence of these lesions may suggest a role for these carcinogens in their induction.