SOLID-PHASE SYNTHESIS OF CHIRAL 3-SUBSTITUTED QUINAZOLINE-2,4-DIONES

Authors
GOUILLEUX L FEHRENTZ JA WINTERNITZ F MARTINEZ J
Citation
L. Gouilleux et al., SOLID-PHASE SYNTHESIS OF CHIRAL 3-SUBSTITUTED QUINAZOLINE-2,4-DIONES, Tetrahedron letters, 37(39), 1996, pp. 7031-7034
Citations number
15
Categorie Soggetti
Chemistry Inorganic & Nuclear
Journal title
Tetrahedron letters → ACNP
ISSN journal
00404039
Volume
37
Issue
39
Year of publication
1996
Pages
7031 - 7034
Database
ISI
SICI code
0040-4039(1996)37:39<7031:SSOC3Q>2.0.ZU;2-E
Abstract
The synthesis of chiral 3-substituted quinazoline-2,4-diones was perfo rmed starting from N-urethane anthranilamides. This synthetic pathway was applied in solid phase, from commercially available anthranilic ac id that was bound to hydroxymethyl polystyrene resin via a carbamate l inker. In both cases, cyclisation occurred under basic conditions to a fford non-racemized quinazolinediones in high purity. Copyright (C) 19 96 Published by Elsevier Science Ltd