ANTI-AIDS COMPOUNDS - A NEW SYNTHESIS OF BETA-THYMIDINE FROM D-XYLOSE

Authors
RAO AVR GURJAR MK LALITHA SVS TRIPATHY S
Citation
Avr. Rao et al., ANTI-AIDS COMPOUNDS - A NEW SYNTHESIS OF BETA-THYMIDINE FROM D-XYLOSE, Proceedings of the Indian Academy of Sciences. Chemical sciences, 106(6), 1994, pp. 1415-1421
Citations number
11
Journal title
Proceedings of the Indian Academy of Sciences. Chemical sciences → ACNP
ISSN journal
02534134
Volume
106
Issue
6
Year of publication
1994
Pages
1415 - 1421
Database
ISI
SICI code
0253-4134(1994)106:6<1415:AC-ANS>2.0.ZU;2-Q
Abstract
beta-thymidine is a key intermediate in the manufacturing of anti-AIDS agents - AZT and d(4) T. A practical and economically viable route to beta-thymidine starting from inexpensive D-xylose has been described. This synthetic route is based on a new rearrangement leading to 2,2'- anhydro-formation with concomitant epimerisation at C-3', observed for the first time in nucleoside chemistry.