FAMILIAL CONGENITAL VALVAR PULMONARY STENOSIS - AUTOSOMAL-DOMINANT INHERITANCE

A mother and three of her four children, one girl and two boys, who ha d valvar pulmonary stenosis are described, One child had an associated septum secundum atrial septal defect, and another had an associated v entricular septal defect. An autosomal dominant mode of inheritance is likely for the valvar pulmonary stenosis, The association of addition al cardiac lesions in two of the three siblings raises the possibility of closely associated genetic loci.