ANTIVIRAL AND IMMUNOLOGICAL ACTIVITY OF A NEW PAVINE ALKALOID (-)-THALIMONINE ISOLATED FROM THALICTRUM-SIMPLEX

Authors
VARADINOVA TL SHISHKOV SA IVANOVSKA ND VELCHEVA MP DANGHAAGHIN S SAMADANGHIIN Z YANSANGHIIN Z
Citation
Tl. Varadinova et al., ANTIVIRAL AND IMMUNOLOGICAL ACTIVITY OF A NEW PAVINE ALKALOID (-)-THALIMONINE ISOLATED FROM THALICTRUM-SIMPLEX, PTR. Phytotherapy research, 10(5), 1996, pp. 414-417
Citations number
17
Categorie Soggetti
Pharmacology & Pharmacy
Journal title
PTR. Phytotherapy research → ACNP
ISSN journal
0951418X
Volume
10
Issue
5
Year of publication
1996
Pages
414 - 417
Database
ISI
SICI code
0951-418X(1996)10:5<414:AAIAOA>2.0.ZU;2-3
Abstract
A pavine alkaloid (-)-thalimonine, at a nontoxic concentration range b etween 0.1 and 100 mu M was investigated for antiviral and immunologic al activity. The alkaloid irreversibly inhibited the replication of he rpes simplex virus type 1 (HSV-1) in MDBK cells with no effect on free virions. The (-)-thalimonine enhanced the proliferation induced by T- cell mitogens (PHA, ConA) at lower concentrations and suppressed the a ction of B-cell mitogen (LPS) in vitro. Splenic cells from mice pretre ated with (-)-thalimonine had an elevated response to PHA and a lowere d response to LPS.