EFFECT OF D-400, AN AYURVEDIC HERBAL FORMULATION ON EXPERIMENTALLY-INDUCED DIABETES-MELLITUS

In the present study, after D-400 treatment a significant reduction in blood sugar levels in alloxan induced diabetes was observed, an oral glucose tolerance test (OGTT) showed a significant lowering of AUC in streptozotocin induced diabetes in rats, There was a rise in hepatic g lycogen level closer to normal after D-400 treatment. In the pancreas of diabetic rats, D-400 therapy showed a significant increase in islet number and beta cell count and appeared to bring about blood glucose homeostasis by increasing insulin secretion through repair/regeneratio n of endocrine pancreas which may be responsible for the prevention of hepatic glycogenolysis.