THE KINETICS OF SKIN THINNING INDUCED BY TOPICAL FLUTICASONE PROPIONATE 0.05-PERCENT CREAM IN VOLUNTEER SUBJECTS

Authors
DYKES PJ MARKS R HILL S MILLS C EASTWOOD R
Citation
Pj. Dykes et al., THE KINETICS OF SKIN THINNING INDUCED BY TOPICAL FLUTICASONE PROPIONATE 0.05-PERCENT CREAM IN VOLUNTEER SUBJECTS, Clinical and experimental dermatology, 21(3), 1996, pp. 180-184
Citations number
13
Categorie Soggetti
Dermatology & Venereal Diseases
Journal title
Clinical and experimental dermatology → ACNP
ISSN journal
03076938
Volume
21
Issue
3
Year of publication
1996
Pages
180 - 184
Database
ISI
SICI code
0307-6938(1996)21:3<180:TKOSTI>2.0.ZU;2-S
Abstract
Fluticasone propionate (FP) 0.05% (Cutivate(TM)) cream is a novel cort icosteroid used for the treatment of corticosteroid-responsive dermato ses. To date there are no published data concerning its effect on cuta neous atrophy. This randomized, double-blind study of 40 volunteer sub jects was performed to investigate the kinetics of skin thinning induc ed by topical 0.05% FP cream vs. placebo after once-daily application for 2-8 weeks. The results of this study showed no significant effect on the skin thickness of subjects after 8 weeks' treatment with 0.05% FP cream compared with placebo.