ACTIVATION OF HEMOLYSIS INDUCED BY PHOTOO XIDIZED PSORALEN (POP) BY FE2- A ROLE OF FE2+ REACTIONS WITH POP AND ERYTHROCYTES( IONS )

Authors
ZHURAVEL NN BELICHENKO IV KYAGOVA AA LYSENKO EP KHALILOV EM POTAPENKO AY
Citation
Nn. Zhuravel et al., ACTIVATION OF HEMOLYSIS INDUCED BY PHOTOO XIDIZED PSORALEN (POP) BY FE2- A ROLE OF FE2+ REACTIONS WITH POP AND ERYTHROCYTES( IONS ), Biologiceskie membrany, 13(4), 1996, pp. 354-360
Citations number
12
Categorie Soggetti
Cell Biology
Journal title
Biologiceskie membrany → ACNP
ISSN journal
02334755
Volume
13
Issue
4
Year of publication
1996
Pages
354 - 360
Database
ISI
SICI code
0233-4755(1996)13:4<354:AOHIBP>2.0.ZU;2-F
Abstract
The effects of Fe2+ ions on hemolysis induced by photooxidized psorale n (POP-hemolysis) were investigated. It was shown that POP-hemolysis w as strongly activated by Fe2+ ions. This effect occurs by two mechanis ms. First Fe2+ ions induce latent damages in erythrocytes, that can be revealed upon the POP action. The second mechanism is the interaction of Fe2+ ions and POP resulting in the generation of free radicals tha t are toxic for erythrocytes.