THE EFFECTS OF MORPHINE ON CARRAGEENAN-INDUCED SPINAL C-FOS EXPRESSION ARE COMPLETELY BLOCKED BY BETA-FUNALTREXAMINE, A SELECTIVE MU-OPIOIDRECEPTOR ANTAGONIST

Citation
P. Honore et al., THE EFFECTS OF MORPHINE ON CARRAGEENAN-INDUCED SPINAL C-FOS EXPRESSION ARE COMPLETELY BLOCKED BY BETA-FUNALTREXAMINE, A SELECTIVE MU-OPIOIDRECEPTOR ANTAGONIST, Brain research, 732(1-2), 1996, pp. 242-246
Citations number
33
Categorie Soggetti
Neurosciences
Journal title
ISSN journal
00068993
Volume
732
Issue
1-2
Year of publication
1996
Pages
242 - 246
Database
ISI
SICI code
0006-8993(1996)732:1-2<242:TEOMOC>2.0.ZU;2-4
Abstract
We have demonstrated that pre-administered morphine (3 mg/kg, i.v.) de creased spinal c-Fos expression induced 2 h after intraplantar carrage enin (55 +/- 5% reduction, P < 0.0001). These effects were completely blocked by pre-administered beta-funaltrexamine (10 mg/kg, i.v., 24 h prior to stimulation) a selective long-lasting mu-opioid receptor anta gonist. In conclusion, these results clearly demonstrate that the effe cts of morphine on noxiously-evoked spinal c-Fos expression are essent ially mediated via mu-opioid receptors.