KAHALALIDES - BIOACTIVE PEPTIDE FROM A MARINE MOLLUSK ELYSIA-RUFESCENS AND ITS ALGAL DIET BRYOPSIS SP

In addition to the previously reported bioactive kahalalide F six new peptides are described. Six of these, including kahalalide F, are cycl ic depsipeptides, ranging from a C-31 tripeptide to a C-75 tridecapept ide isolated from a sacoglossan mollusk, Elysia rufescens. The mollusk feeds on a green alga, Bryopsis sp., which has also been shown to ela borate some of these peptides in smaller yields, in addition to an acy clic analog of F, kahalalide G. The bioassay results of antitumor, ant iviral, antimalarial, and OI (activity against AIDS opportunistic infe ctions) tests are reported.