NEUTRAL-LIPID TRANSFERS AND CHOLESTERYL ESTER TRANSFER PROTEIN IN HEMODIALYZED PATIENTS

Abnormalities in cholesteryl ester transfers may play a role in the de velopment of atherosclerosis observed in patients with end-stage renal failure treated by chronic hemodialysis. Net neutral-lipid transfers and cholesteryl ester transfer protein activity and mass were investig ated in 20 hemodialyzed patients, arbitrarily divided into two groups based on fasting triglyceride levels, and compared to triglyceride-mat ched control groups. In the hypertriglyceridemic subjects (plasma trig lyceride values > 150 mg/dl), high-density lipoprotein cholesterol was decreased, and the net cholesteryl ester transfer rates were signific antly higher than the rates in normolipidemic subjects. The comparison of subjects matched for plasma triglyceride and cholesterol levels sh owed no significant difference in cholesteryl ester or triglyceride tr ansfer rates between patients and controls. Our results suggest that n ormal or elevated net neutral-lipid transfers are not related to the r enal status of the subjects, but rather to their plasma triglyceride l evels.