Adenosine is considered an important neuromodulator of the nervous sys
tem acting at pre-, post- and non-synaptic levels. In the present revi
ew we describe how adenosine modifies paired-pulse facilitation (PPF),
posttetanic depression (PTD), long-term potentiation (LTP), long-term
depression (LTD) and depotentiation at the hippocampus, and therefore
how this nucleoside modulates synaptic plasticity.