HEPATOTOXIC SIDE-EFFECT OF CLOMETHIAZOLE

We report on a patient with a history of alcoholism who developed hype rbilirubinemia induced by treatment with clomethiazole during two hosp italizations. After discontinuation of clomethiazole symptoms of cholo stasis improved. Clomethiazole is a thiazole analogon and is chemicall y related to thiamine (vitamine B-1). It can be administered as tablet s, capsules, mixtures, and a 0.8% solution. Because of its sedative, h ypnotic, and anticonvulsive effects it is used in the treatment of alc oholic delirium.