ARTERIOVENOUS MALFORMATION ANIMAL-MODEL FOR RADIOSURGERY - THE RETE-MIRABILE

Citation
Aaf. Desalles et al., ARTERIOVENOUS MALFORMATION ANIMAL-MODEL FOR RADIOSURGERY - THE RETE-MIRABILE, American journal of neuroradiology, 17(8), 1996, pp. 1451-1458
Citations number
36
Categorie Soggetti
Clinical Neurology","Radiology,Nuclear Medicine & Medical Imaging
ISSN journal
01956108
Volume
17
Issue
8
Year of publication
1996
Pages
1451 - 1458
Database
ISI
SICI code
0195-6108(1996)17:8<1451:AMAFR->2.0.ZU;2-O
Abstract
PURPOSE: To study the effects of single-dose radiation on the porcine rete mirabile, a tangle of microvessels that mimics human arteriovenou s malformations of the brain. METHODS: Eight retia mirabilia received a single dose of radiation under stereotactic location with digital an giography and CT. The following doses were applied: 20, 30, 40, 50, 60 , 70, 80, and 90 Gy. The animals were followed up for a period of 7 mo nths. Findings at neurologic examination, serial angiography, and hist opathologic examination were analyzed. RESULTS: Progressive occlusion as observed by angiography corresponded to the histopathologic finding of intimal hyperplasia; that is, marked thickening of the vessel wall , progressing to occlusion of the vascular lumen, and associated throm bosis. A direct dose response was noted for these changes. Neurologic findings were related to the dose distribution and to histologic findi ngs in structures adjacent to the rete mirabile. CONCLUSION: The rete mirabile is an excellent model by which to study the radiologic and hi stologic effects of single-dose radiation to the microvasculature of t he central nervous system.