Aaf. Desalles et al., ARTERIOVENOUS MALFORMATION ANIMAL-MODEL FOR RADIOSURGERY - THE RETE-MIRABILE, American journal of neuroradiology, 17(8), 1996, pp. 1451-1458
Citations number
36
Categorie Soggetti
Clinical Neurology","Radiology,Nuclear Medicine & Medical Imaging
PURPOSE: To study the effects of single-dose radiation on the porcine
rete mirabile, a tangle of microvessels that mimics human arteriovenou
s malformations of the brain. METHODS: Eight retia mirabilia received
a single dose of radiation under stereotactic location with digital an
giography and CT. The following doses were applied: 20, 30, 40, 50, 60
, 70, 80, and 90 Gy. The animals were followed up for a period of 7 mo
nths. Findings at neurologic examination, serial angiography, and hist
opathologic examination were analyzed. RESULTS: Progressive occlusion
as observed by angiography corresponded to the histopathologic finding
of intimal hyperplasia; that is, marked thickening of the vessel wall
, progressing to occlusion of the vascular lumen, and associated throm
bosis. A direct dose response was noted for these changes. Neurologic
findings were related to the dose distribution and to histologic findi
ngs in structures adjacent to the rete mirabile. CONCLUSION: The rete
mirabile is an excellent model by which to study the radiologic and hi
stologic effects of single-dose radiation to the microvasculature of t
he central nervous system.