WHIPPLE DISEASE CONFINED TO THE CENTRAL-NERVOUS-SYSTEM IN CHILDHOOD

In a case of pediatric Whipple disease confined to the central nervous system, white matter lesions initially appeared as areas of very low signal intensity on T1-weighted MR images and as areas of hyperintensi ty on proton density-weighted and T2-weighted images, and showed sligh t peripheral enhancement on delayed contrast-enhanced T1-weighted imag es. On MR studies obtained 3 and 6 months after antibiotic therapy, th e lesions had decreased in size and no longer enhanced. They became pr ogressively less hypointense on T1-weighted images and less hyperinten se on T2-weighted images.