SIMPLE EXTRACTION OF PHENCYCLIDINE FROM HUMAN-BODY FLUIDS BY HEADSPACE SOLID-PHASE MICROEXTRACTION (SPME)

Phencyclidine (PCP) was found to be extractable by headspace solid-pha se microextraction (SPME) from human whole blood and urine. Sample sol utions were heated at 90 degrees C in the presence of NaOH and K2CO3, and an SPME fiber was exposed in the headspace of a vial for 30 min. I mmediately after withdrawal of the fiber, it was analyzed by gas chrom atography with surface ionization detection (GC-SID). Recoveries of PC P were approximately 9.3-10.8 % and 39.8-47.8 % for whole blood and ur ine samples, respectively. The calibration curve for PCP showed good l inearity in the range 2.5-100 ng mL(-1) whole blood and 0.5-100 ng mL( -1) urine. The detection limits were approximately 1.0 ng mL(-1) for w hole blood and 0.25 ng mL(-1) for urine.