CEFTRIAXONE-ASSOCIATED NEPHROLITHIASIS - 2 CASE-REPORTS

Ceftriaxone (Rocephin(R)) is often used in treatment of severe bacteri al infections. The appearance of precipitations in the gall bladder is a well-known adverse effect under Ceftriaxone therapy. To our knowled ge only two cases of Ceftriaxone-assaciated nephrolithiasis have been published before. We report two further cases of patients with renal s ide effects under treatment with Ceftriaxone: A 6-year-old boy develop ed nephrolithiasis with unilateral obstruction of the urinary tract, a nd a 9-year-old girl an acute postrenal insufficiency with anuria. In both cases it was documented by infrared spectroscopy and mass spectro metry that urine stone-formations contained Ceftriaxone-compounds. Suf ficient fluid supply is necessary to avoid renal side effects. In all patients with hematuria or abdominal pain the urinary tract shoud be e xplored by ultrasonography.