ADVANTAGES AND DISADVANTAGES OF DOBUTAMINE STRESS ECHOCARDIOGRAPHY COMPARED WITH TREADMILL EXERCISE ELECTROCARDIOGRAPHY IN DETECTING ISCHEMIA

We compared the effectiveness and practicability of dobutamine stress echocardiography (DSE) and treadmill exercise electrocardiographic tes ting (TMT) for detecting coronary artery disease. Ninety-six patients (mean age 58.8 +/- 9.0 years) who presented for coronary angiography u nderwent both DSE and symptom-limited TMT. Two-dimensional echocardiog raphy was performed to detect ischemia-induced wall motion abnormaliti es during incremental dobutamine infusion (5-40 mu g/kg per min admini stered in 5 min steps). The sensitivity of detecting ischemia was 63% for TMT and 79% for DSE (p < 0.05); the specificity was 61% for TMT an d 88% for DSE (p < 0.05). The accuracy of TMT was 63% and of DSE 82% ( p < 0.01). In patients in whom both tests gave true-positive results, the maximum ST depression was evaluated during DSE and TMT (n = 31). T he ST segment depressions detected by DSE were significantly smaller t han those detected by TMT (0.04 +/- 0.04 mV vs 0.17 +/- 0.07 mV, p < 0 .01), and 10 patients had no evidence of ST segment depression despite the presence of new wall motion abnormalities. DSE took significantly longer to perform than TMT (26.0 +/- 5.0 min vs 5.5 +/- 2.0 min, p < 0.01). Thus, DSE is more sensitive, specific and accurate than TMT in detecting coronary artery disease and can detect ischemia at an earlie r stage. However, it takes longer to perform than TMT and thus may be less suitable for routine clinical use.