TRISOMY-20 IN A PAPILLARY UROTHELIAL CARCINOMA OF THE URETER

To contribute to the knowledge on tumorigenesis and the evolution of u rothelial carcinoma of the ureter, we analyzed the clinical, histologi cal, and cytogenetic aspects of a case. Primary cell cultures obtained from tumor specimens showed a trisomy of chromosome 20 where the c-sr c proto-oncogene, already described in literature as having an importa nt role in the etiology and progression of some tumors, is located. In our case trisomy 20 is the only present marker and for this reason we think that it could play a role in the tumorigenesis of the urothelia l carcinoma of the ureter.