DIMETHYL FORMAMIDE (DMFA) AND ETHYLENE-GLYCOL (EG) ARE ESTROGENIC IN RAINBOW-TROUT

Authors
REN LF MELDAHL A LECH JJ
Citation
Lf. Ren et al., DIMETHYL FORMAMIDE (DMFA) AND ETHYLENE-GLYCOL (EG) ARE ESTROGENIC IN RAINBOW-TROUT, Chemico-biological interactions, 102(1), 1996, pp. 63-67
Citations number
6
Categorie Soggetti
Toxicology,Biology,Chemistry,Biology
Journal title
Chemico-biological interactions → ACNP
ISSN journal
00092797
Volume
102
Issue
1
Year of publication
1996
Pages
63 - 67
Database
ISI
SICI code
0009-2797(1996)102:1<63:DF(AE(>2.0.ZU;2-N
Abstract
During our studies on the effects of environmental estrogenic chemical s on vitellogenin gene expression in fish, dimethyl formamide (DMFA) a nd ethylene glycol (EG) were used as solvents to dissolve and deliver hydrophobic beta-estradiol or nonylphenol. Control groups were injecte d with water only. It was surprising to find that in certain doses, Vg mRNA from control fish can be induced by DMFA or EG alone. This sugge sted that DMFA and EG are weak estrogens.