SYNTHESIS OF GLA-60 POSITIONAL ISOMER AS AN LPS-AGONIST AND ITS ACTIVITY

Authors
SHIOZAKI M ARAI M MACINDOE WM MOCHIZUKI T KURAKATA S MAEDA H NISHIJIMA M
Citation
M. Shiozaki et al., SYNTHESIS OF GLA-60 POSITIONAL ISOMER AS AN LPS-AGONIST AND ITS ACTIVITY, Chemistry Letters, (9), 1996, pp. 735-736
Citations number
15
Categorie Soggetti
Chemistry
Journal title
Chemistry Letters → ACNP
ISSN journal
03667022
Issue
9
Year of publication
1996
Pages
735 - 736
Database
ISI
SICI code
0366-7022(1996):9<735:SOGPIA>2.0.ZU;2-C
Abstract
Compound 10 was synthesized from beta-D-glucose pentaacetate in a ster eocontrolled manner. It unexpectedly showed LPS-agonistic activity muc h stronger than that of GLA-60 toward human monoblastic U937 cells in the TNF alpha production.