DESIGNING REFERENCE PANELS OF SERA WITH S TANDARD LEVELS OF IGG ANTIBODIES

Fundamentals of designing reference panels of sera for effective contr ol of commercial test systems and immunoblotting, intended for detecti ng antiviral antibodies, have been developed. Reference low-titer pane ls of anti-IgG antibodies to HIV-a and hepatitis C virus have been des igned. A reference panel contains diluted reactive sera with a standar d level of IgG antibodies and native sera with undetectable level of a ntibodies to the major viral antigens from risk-group subjects. The re active sera of a panel contain the whole spectrum of antibodies to all principal viral antigens.