CONTRIBUTION OF INFLUENZA-VIRUS HEMAGGLUT ININ TO ANTICOAGULATION PROCESSES

Influenza virus hemagglutinin (HA) possesses anticoagulant and fubrino lytic activities and affects such blood clotting factors as fibrinogen and factor XIII in vitro and in vivo. Computer analysis of HA structu re of avian, animal, and human type 1 influenza, viruses showed 1 or 2 sites of amino acid sequences similar to plasminogen activator. These sites proved to be highly conservative for each virus subtype, irresp ective of the source and year of isolation of the strain. Evolution re lationships with respect to this sign were detected between the studie d viruses.