ANGIOTENSIN-CONVERTING ENZYME-INHIBITION AND PROTEIN RESTRICTION IN PROGRESSION OF EXPERIMENTAL CHRONIC-RENAL-FAILURE

This study examined whether the effects of protein restriction and ang iotensin converting enzyme (ACE) inhibition on the progression of rena l failure are common or additive. Male Sprague Dawley rats (12 wks of age) underwent 5/6 nephrectomy and were randomized to 20% protein diet (PD) (n=9), 20% PD+enalapril (5 mg/kg/day) (n=10), 20% PD+felodipine (30 mg/kg/day) (n=9), 6% PD (n=9), 6% PD+enalapril (n=9) or 6% PD+felo dipine (n=10). Protein restriction, enalapril or felodipine treatment all retarded progression of renal failure and development of glomerula r lesions. Protein restriction and enalapril appeared to have additive effects in preventing glomerular sclerosis.