Vk. Ahluwalia et B. Goyal, ONE-POT SYNTHESIS OF -HEXAHYDRO-2,7,7-TRIMETHYLQUINOLINE-3-CARBOXYLATES, Indian journal of chemistry. Sect. B: organic chemistry, including medical chemistry, 35(10), 1996, pp. 1021-1025
Synthesis of substituted 5,6,7,8-hexahydro-2,7,7-trimethyl-5-oxo-quino
lines 4a-f has been carried out by the condensation of 5,5-dimethylcyc
lohexane-1,3-dione 1, aromatic aldehyde 2 and methyl beta-aminocrotona
te 3a. Use of ethyl acetoacetate 3b in place of 3a gives the correspon
ding 3-carbethoxy compounds 5a-g. Alternatively, the compound 5b has a
lso been synthesized by the condensation of 1 with ethyl 2-(2'-nitrobe
nzylidene)acetoacetate in liquor ammonia.