SYNTHESIS AND ANTICONVULSANT ACTIVITY OF SOME SPIRO COMPOUNDS DERIVEDFROM BARBITURIC AND THIOBARBITURIC ACIDS .1.

Authors
OSMAN AN KANDEEL MM SAID MM AHMED EM
Citation
An. Osman et al., SYNTHESIS AND ANTICONVULSANT ACTIVITY OF SOME SPIRO COMPOUNDS DERIVEDFROM BARBITURIC AND THIOBARBITURIC ACIDS .1., Indian journal of chemistry. Sect. B: organic chemistry, including medical chemistry, 35(10), 1996, pp. 1073-1078
Citations number
17
Categorie Soggetti
Chemistry Inorganic & Nuclear
Journal title
Indian journal of chemistry. Sect. B: organic chemistry, including medical chemistry → ACNP
ISSN journal
03764699
Volume
35
Issue
10
Year of publication
1996
Pages
1073 - 1078
Database
ISI
SICI code
0376-4699(1996)35:10<1073:SAAAOS>2.0.ZU;2-5
Abstract
Divinyl ketones (1), prepared by the condensation of acetone with the appropriate aromatic aldehydes, on Michael addition with barbituric an d thiobarbituric acids afford the desired spiro compounds (2a-j). The ketoximes (3a-j) obtained from 2a-j on Beckmann transformation by trea tment with PCl5 furnish the spiro azepines (4a-j). Alkylation of some of the compounds 2 afford the anticipated N-substituted products (5a-i ). Preliminary pharmacological screening of some of the new compounds reveal their anticonvulsant activity.