LOW-DOSE IMIPRAMINE FOR THIORIDAZINE-INDUCED MALE ORGASMIC DISORDER

Male orgasmic disorder is commonly encountered among patients treated with thioridazine. This side effect interferes significantly with sexu al satisfaction. In this pilot study, eight male schizophrenic patient s who complained of orgasmic disorder, compatible with probable retrog rade ejaculation during thioridazine treatment, were given concomitant low-dose imipramine (25-50 mg at bedtime). Four of the eight reported complete resumption of their previous ejaculatory function, and in on e patient there was a partial, but substantial, improvement. Three pat ients noted no change. It appears that imipramine might be beneficial for some patients with thioridazine-induced male orgasmic disorder.