SLIPPED CAPITAL FEMORAL EPIPHYSIS IN CHILDREN TREATED WITH GROWTH-HORMONE - A SUMMARY OF THE NATIONAL COOPERATIVE GROWTH STUDY EXPERIENCE

We examined the association between slipped capital femoral epiphysis (SCFE) and growth hormone (GH) treatment in 16,514 children who had no t been treated with GH prior to their enrollment in the National Coope rative Growth Study. Fifteen children had SCFE prior to receiving GH t herapy, 26 developed SCFE during GH treatment, and one had SCFE on one side prior to GH treatment and developed it on the contralateral side while receiving GH. Children with GH deficiency were significantly mo re likely to develop SCFE while on GH treatment than were children wit h idiopathic short stature (p = 0.006). There was no difference betwee n GH-deficient girls and boys in the risk of developing SCFE during GH treatment. There were 3 cases of SCFE in girls with Turner syndrome b efore GH treatment and 3 during. Typically, children who developed SCF E while on GH were older, heavier, and grew more slowly during the fir st year of GH than those who did not. Children with GH deficiency, Tur ner syndrome, and other known causes of short stature are more likely to develop SCFE before or during GH treatment than children with idiop athic short stature.