The cerebral organization of word identification processes in reading
was examined using functional magnetic resonance imaging (fMRI). Chang
es in fMRI signal intensities were measured in 38 subjects (19 males a
nd 19 females) during visual (line judgement), orthographic (letter ca
se judgement), phonological (nonword rhyme judgement) and semantic (se
mantic category judgement) tasks. A strategy of multiple subtractions
was employed in order to validate relationships between structure and
function. Orthographic processing made maximum demands on extrastriate
sites, phonological processing on a number of frontal and temporal si
tes, and lexical-semantic processing was most strongly associated with
middle and superior temporal sites. Significant sex differences in th
e cerebral organization of reading-related processes were also observe
d.