In this review, we aim to bring together major trends in autism resear
ch at three levels: biology, behaviour and cognition. We propose that
cognitive theories are vital in neuropsychology, which seeks to make c
onnections between brain abnormality and behavioural symptoms. Researc
h at each of the three levels is incomplete, but important advances ha
ve been made. At the biological level, there is strong evidence for ge
netic factors, although the mechanism is, as yet, unknown. At the beha
vioural level, diagnosis and education are becoming more coherent and
less controversial, although the possibility of autism subtypes has pr
ovoked new debate. At the cognitive level, three major theories are pr
oving fruitful (mentalizing impairment, executive dysfunction and weak
central coherence), although the relation and overlap between these i
s uncertain. Rapidly advancing technology and methodology (e.g. brain
imaging, gene mapping), as tools of cognitive theory may help to make
autism one of the first developmental disorders to be understood at th
e neuropsychological level.