TRANSGENIC MICE OVEREXPRESSING METALLOTHIONEIN ARE NOT RESISTANT TO ADRIAMYCIN CARDIOTOXICITY

Authors
DISILVESTRO RA LIU J KLAASSEN CD
Citation
Ra. Disilvestro et al., TRANSGENIC MICE OVEREXPRESSING METALLOTHIONEIN ARE NOT RESISTANT TO ADRIAMYCIN CARDIOTOXICITY, Research communications in molecular pathology and pharmacology, 93(2), 1996, pp. 163-170
Citations number
16
Categorie Soggetti
Pharmacology & Pharmacy",Pathology,Biology
Journal title
Research communications in molecular pathology and pharmacology → ACNP
ISSN journal
10780297
Volume
93
Issue
2
Year of publication
1996
Pages
163 - 170
Database
ISI
SICI code
1078-0297(1996)93:2<163:TMOMAN>2.0.ZU;2-V
Abstract
Metallothionein (MT) induction, particularly by bismuth, is proposed t o protect against toxic side effects of chemotherapy drugs such as adr iamycin. In contrast, transgenic mice, which overexpressed cardiac MT, and also had moderately high heart glutathione concentrations, were n ot resistant to adriamycin-induced cardiotoxicity. Cardiotoxicity was assessed by survival, fluid accumulation and lipid peroxidation, Thus, higher than normal heart MT concentrations do not necessarily protect against adriamycin cardiotoxicity.