Although mechanical loading associated with exercise participation can
lead to positive bone adaptation,(1,2) structural damage may result i
f loading is excessive. Stress fractures represent one form of breakdo
wn in the skeleton.(3) They can be defined as partial or complete frac
tures of bone that result from the repeated application of a stress le
ss than that required to fracture bone in a single loading situation.(
4) While it is apparent that stress fracture development involves repe
titive loading and the processes of both bone fatigue, with microdamag
e accumulation, and remodelling, the exact pathogenesis is unknown. Ba
sed on a review of published reports, we shall present two possible mo
dels for the pathogenesis of stress fractures in athletes. Understandi
ng the pathogenesis may aid in the identification of factors which pla
ce an athlete at increased risk for this sports injury.