DEFECTIVE GROWTH-HORMONE SECRETION IN CHILDREN WITH PYCNODYSOSTOSIS AND IMPROVED LINEAR GROWTH AFTER GROWTH-HORMONE TREATMENT

Authors
SOLIMAN AT RAJAB A ALSALMI I DARWISH A ASFOUR M
Citation
At. Soliman et al., DEFECTIVE GROWTH-HORMONE SECRETION IN CHILDREN WITH PYCNODYSOSTOSIS AND IMPROVED LINEAR GROWTH AFTER GROWTH-HORMONE TREATMENT, Archives of Disease in Childhood, 75(3), 1996, pp. 242-244
Citations number
7
Categorie Soggetti
Pediatrics
Journal title
Archives of Disease in Childhood → ACNP
ISSN journal
00039888
Volume
75
Issue
3
Year of publication
1996
Pages
242 - 244
Database
ISI
SICI code
0003-9888(1996)75:3<242:DGSICW>2.0.ZU;2-8
Abstract
Short stature is a characteristic feature of pycnodysostosis. We repor t defective growth hormone secretion in response to provocation and lo w insulin-like growth factor-I (IGF-I) concentration in five out of si x patients with pycnodysostosis. Physiological replacement with growth hormone increased IGF-I concentration and improved linear growth in t hese children.