SYNTHESIS OF 4(4-FLUOROPHENYL)-2,3-DIHYDRO-1,5-BENZOTHIAZEPINES

Authors
UPRETI M PANT S DANDIA A PANT UC
Citation
M. Upreti et al., SYNTHESIS OF 4(4-FLUOROPHENYL)-2,3-DIHYDRO-1,5-BENZOTHIAZEPINES, Phosphorus, sulfur and silicon and the related elements, 113(1-4), 1996, pp. 165-171
Citations number
39
Categorie Soggetti
Chemistry Inorganic & Nuclear
Journal title
Phosphorus, sulfur and silicon and the related elements → ACNP
ISSN journal
10426507
Volume
113
Issue
1-4
Year of publication
1996
Pages
165 - 171
Database
ISI
SICI code
1042-6507(1996)113:1-4<165:SO4>2.0.ZU;2-R
Abstract
Syntheses of six -2-carboxy-4-(4-fluorophenyl)-1,5-benzothiazepines ha ving as the substituent fluoro, chloro, bromo, alkyl-methyl, alkoxyl-m ethoxyl and ethoxyl have been achieved by the reaction of 5-substitute d-2-aminobenzenethiols with beta(-p-fluorobenzoyl)acrylic acid in etha nol saturated with hydrogen chloride gas. The products were tested for purity by TLC. Microestimation of nitrogen, IR and H-1 NMR & mass spe ctral studies have been used for the assignment of structures to the t itle compounds.