BIOLOGICAL-ACTIVITY OF 4-(4-BROMOPHENYL)THIOSEMICARBAZIDE

The two molecules (A and B) in the asymmetric unit of the title compou nd, C7H8BrN3S; display different conformations. In both molecules, the S atom is trans to the NH2 group. The Br atoms of the two molecules a pproach each other at a distance of 3.573(2)Angstrom. The crystal stru cture of the bromine compound is isomorphous with that of its chlorine analogue. In the crystal structure, intramolecular N-H ... N and inte rmolecular N-H ... S hydrogen bonds help stabilize the molecular packi ng. The increased antibacterial activity of the title compound compare d to that of its chlorine analogue may be attributed to the increase i n electron density on the hydrazinic end of the thiosemicarbazide chai n.