INHIBITION OF LUNG HOMING OF B16F10 BY PENTOXIFYLLINE, A MICROFILAMENT DEPOLYMERIZING AGENT

B16 melanoma has proved to be an ideal model for investigating metasta sis, The parental B16F1 line grows as a localized subcutaneous tumor i n C57BL/6 or DBA/2 mice. However, by means of successive intravenous t ransplantation, a subline B16F10 has been established. This shows prep onderant lung homing when transplanted by intravenous route into C57BL /6 mice. In this paper we have shown that pentoxifylline (PTX; Hoechst ), a microfilament depolymerising agent can inhibit significantly this lung homing of B16F10 cells. It also had a marginal inhibitory effect on subcutaneous tumor growth.