Rp. Gude et al., INHIBITION OF LUNG HOMING OF B16F10 BY PENTOXIFYLLINE, A MICROFILAMENT DEPOLYMERIZING AGENT, Cancer letters, 106(2), 1996, pp. 171-176
B16 melanoma has proved to be an ideal model for investigating metasta
sis, The parental B16F1 line grows as a localized subcutaneous tumor i
n C57BL/6 or DBA/2 mice. However, by means of successive intravenous t
ransplantation, a subline B16F10 has been established. This shows prep
onderant lung homing when transplanted by intravenous route into C57BL
/6 mice. In this paper we have shown that pentoxifylline (PTX; Hoechst
), a microfilament depolymerising agent can inhibit significantly this
lung homing of B16F10 cells. It also had a marginal inhibitory effect
on subcutaneous tumor growth.