Every so often in the history of medicine, events occur which in retro
spect seem to mark a defining moment. For psychiatry, the decade of th
e 1950s uses one such 'moment'. On 28 December 1951, J. Sigwold starte
d solo chlorpromazine treatment of a 57-year-old psychotic lady and, t
hereby, it might be argued, began the modern era of psychopharmacology
.