MALIGNANT ECCRINE POROMA WITH MULTIPLE VISCERAL METASTASES - REPORT OF A CASE WITH AUTOPSY FINDINGS

An autopsy case of malignant eccrine poroma (MEP) with multiple viscer al metastases is reported. A flat, dark tumor of 1 cm in diameter deve loped on a pre-existing pigmented spot at the left side of the waist o f a 58-year-old male. The histopathology suggested the tumor to be mal ignant melanoma. Nine years later, a painless swelling occurred in the left lower leg, resulting from the obstruction of lymphatics at the l eft inguinal region. The swelling continued and spread with pain, reac hing the inguinal region. Two years later, several papules appeared ar ound the left knee, from which an extensive lymphorrhea occurred. The histopathology of the resected papules suggested epidermoid carcinoma or trichilemmal carcinoma, mainly localized within the lymphatics of t he upper dermis. Re-examination of the first skin tumor and electron m icroscopy of the tumor obtained at autopsy revealed that both tumors w ere MEP. Although the metastases to the local cutaneous regions and ly mph nodes via the lymphatics occur in 20% of MEP, cases with multiple visceral metastases are very few. (C) Munksgaard 1996.