METHODS OF MEASURING SUSCEPTIBILITY OF ANAEROBIC-BACTERIA TO TROVAFLOXACIN, INCLUDING QUALITY-CONTROL PARAMETERS

Three methods approved by the National Committee for Clinical Laborato ry Standards for testing the susceptibility of anaerobic bacteria were used to evaluate the fluoroquinolone, trovafloxacin. The methods gave essentially comparable results with 126 anaerobes and with three qual ity control strains. A collaborative study defined the quality control range for trovafloxacin MICs. Trovafloxacin had good in vitro activit y against the more common anaerobes (MIC 90 less than or equal to 2.0 mu g/ml).