IN-VITRO ACTIVITY AND SELECTION OF DISK CONTENT FOR DISK DIFFUSION SUSCEPTIBILITY TESTS WITH TROVAFLOXACIN

The activity of the new fluoroquinolone trovafloxacin (CP-99,219) was compared with that of ciprofloxacin and ofloxacin against 517 bacteria l isolates representing 50 different species. Against members of the f amily Enterobacteriaceae, all three drugs showed good in vitro activit y. Against most anaerobic bacteria, Staphylococcus, Streptococcus, and Enterococcus species, trovafloxacin was four- to sixteenfold more act ive than ciprofloxacin. For disk diffusion testing, 10 mu g trovafloxa cin disks gave satisfactory results. Tentative criteria are proposed f or use during clinical studies.