IN-VITRO ACTIVITY OF TROVAFLOXACIN VERSUS CIPROFLOXACIN AGAINST CLINICAL ISOLATES

The comparative in vitro activity of trovafloxacin (CP 99,219), a new fluoroquinolone, was evaluated against 511 clinical isolates. MICs of trovafloxacin were fourfold higher than those of ciprofloxacin for 184 Enterobacteriaceae and 110 non-fermentative gram-negative bacilli. Ho wever, trovafloxacin was 16-fold more active than ciprofloxacin agains t 162 gram-positive staphylococci, pneumococci, streptococci, and ente rococci, and two- to fourfold more active against Haemophilus influenz ae and Moraxella catarrhalis. MICs of trovafloxacin were corresponding ly higher for strains with acquired resistance to ciprofloxacin.