IN-VITRO ACTIVITY OF TROVAFLOXACIN IN COMBINATION WITH CEFTAZIDIME, MEROPENEM, AND AMIKACIN

The in vitro activity of trovafloxacin alone and in combination with c eftazidime, meropenem, and amikacin was studied by determining the min imal inhibitory concentrations (MICs) for 111 gramnegative and 71 gram -positive bacteria. In addition, the synergy of these combinations aga inst 46 strains of gram-negative and gram-positive organisms was studi ed by checkerboard titration and time-kill kinetics. Trovafloxacin exh ibited excellent in vitro activity against all strains tested. Synergi sm was observed in 17% of the gram-negative strains and in 32% of the gram-positive strains. No antagonism was observed with any of the comb inations tested.