SCANNING-TUNNELING-MICROSCOPY STUDY OF CYTOCHROME-P450 2B4 INCORPORATED IN PROTEOLIPOSOMES

Authors
UVAROV VY IVANOV YD ROMANOV AN GALLYAMOV MO KISELYOVA OI YAMINSKY IV
Citation
Vy. Uvarov et al., SCANNING-TUNNELING-MICROSCOPY STUDY OF CYTOCHROME-P450 2B4 INCORPORATED IN PROTEOLIPOSOMES, Biochimie, 78(8-9), 1996, pp. 780-784
Citations number
16
Categorie Soggetti
Biology
Journal title
Biochimie → ACNP
ISSN journal
03009084
Volume
78
Issue
8-9
Year of publication
1996
Pages
780 - 784
Database
ISI
SICI code
0300-9084(1996)78:8-9<780:SSOC2I>2.0.ZU;2-E
Abstract
In the present paper, the application of scanning tunneling microscopy in cytochrome P450s membrane topology is discussed. The method enable s visualization of heme location in the lipid-bilayer-incorporated pro tein. It is supposed that the membrane-bound cytochrome P450 on the tu nneling microscope substrate should behave as 'molecular diode'. A mod el explaining the liposome and the proteoliposome images observed is p roposed.