PROGESTERONE LOADED CHITOSAN MICROSPHERES EFFECT OF TRIETHYLENE GLYCOL GLUTARATE LINKED TO THE CHITOSAN MOLECULE ON DRUG-RELEASE

Authors
ORIENTI I AIEDEH K PONTI C GIANASI E ZECCHI V
Citation
I. Orienti et al., PROGESTERONE LOADED CHITOSAN MICROSPHERES EFFECT OF TRIETHYLENE GLYCOL GLUTARATE LINKED TO THE CHITOSAN MOLECULE ON DRUG-RELEASE, STP pharma sciences, 6(6), 1996, pp. 424-429
Citations number
10
Categorie Soggetti
Pharmacology & Pharmacy
Journal title
STP pharma sciences → ACNP
ISSN journal
11571489
Volume
6
Issue
6
Year of publication
1996
Pages
424 - 429
Database
ISI
SICI code
1157-1489(1996)6:6<424:PLCMEO>2.0.ZU;2-8
Abstract
The preparation of microspheres of chitosan or chitosan linked to trie thylene glycol glutarate containing progesterone is described and the correlations between the formulative parameters and the functional pro perties analysed. Higher loading levels and water uptake were observed for the substituted micromatrices. Kinetics approaching zero order we re observed in each case, and the approach was more evident for the ch itosan substituted micromatrices. These effects are analysed in terms of polymer/drug interactions as determined by the phase solubility dia grams.