Objective-To determine whether HLA type is associated with career prog
ress in rheumatology. Design-Comparison of HLA type after HLA analysis
of samples of venous blood. Setting-Department of Rheumatology Resear
ch, University of Birmingham. Subjects-All (37) staff in the departmen
t. Results-All the senior academics and most staff with a PhD expresse
d HLA-DR4. The prevalence of expression in each of these groups was si
gnificantly greater than that found in the controls. None of the junio
r doctors or secretaries expressed DR4. Conclusion-The junior doctors
in the department have poor career prospects as HLA-DR4 seems to be as
sociated with academic achievement.