TOPICAL ISOTRETINOIN IN DARIERS-DISEASE

Topical 0.05% isotretinoin (Isotrex(R) gel) was used to treat a test p atch of skin in 11 patients with Darier's disease, Hyperkeratosis and papules improved in six patients after treatment for 3 months, Erythem a, burning and irritation were common adverse effects, and these were severe in three patients, one of whom stopped treatment. Patients with mild Darier's disease may find topical isotretinoin helpful, but it i s likely that most patients with widespread disease will require treat ment with systemic retinoids.