A QUANTITATIVE STRUCTURE-ACTIVITY RELATIONSHIP STUDY ON SOME CHOLECYSTOKININ ANTAGONISTS

A quantitative structure-activity relationship (QSAR) study is made on three different series of cholecystokinin (CCK) antagonists, namely a series of 3-(3-indolylmethyl)-1, 4-benzodiazepines, a series of gluta mic acid analogues, and a series of indole derivatives of quinazolinon e. An analysis of this study leads to suggest that CCK antagonists pri marily bind with the receptor through hydrogen bonds and/or hydrophobi c interactions, and that this binding is further strengthened by the i nvolvement of certain substituents in some secondary bindings through, most likely, dispersion interactions.