Sp. Gupta et al., A QUANTITATIVE STRUCTURE-ACTIVITY RELATIONSHIP STUDY ON SOME CHOLECYSTOKININ ANTAGONISTS, Quantitative structure-activity relationships, 14(5), 1995, pp. 437-443
A quantitative structure-activity relationship (QSAR) study is made on
three different series of cholecystokinin (CCK) antagonists, namely a
series of 3-(3-indolylmethyl)-1, 4-benzodiazepines, a series of gluta
mic acid analogues, and a series of indole derivatives of quinazolinon
e. An analysis of this study leads to suggest that CCK antagonists pri
marily bind with the receptor through hydrogen bonds and/or hydrophobi
c interactions, and that this binding is further strengthened by the i
nvolvement of certain substituents in some secondary bindings through,
most likely, dispersion interactions.