NEW ROUTE TO AMINO [H-2(2)]METHYLPHOSPHONIC ACID VIA BIS(TRIFLUOROETHYL) PHOSPHONATE TRANSESTERIFICATION

Authors
BERTEVERRANDO S DIZIERE R SAMADI M SAVIGNAC P
Citation
S. Berteverrando et al., NEW ROUTE TO AMINO [H-2(2)]METHYLPHOSPHONIC ACID VIA BIS(TRIFLUOROETHYL) PHOSPHONATE TRANSESTERIFICATION, Journal of the Chemical Society. Perkin transactions. I, (24), 1995, pp. 3125-3127
Citations number
21
Categorie Soggetti
Chemistry Inorganic & Nuclear
Journal title
Journal of the Chemical Society. Perkin transactions. I → ACNP
ISSN journal
0300922X
Issue
24
Year of publication
1995
Pages
3125 - 3127
Database
ISI
SICI code
0300-922X(1995):24<3125:NRTA[A>2.0.ZU;2-2
Abstract
Transesterification of bis(trifluoroethyl) chloromethyl- and azidometh yl-phosphonates with alcohols in the presence of catalytic quantities of alcoholates gives dialkyl chloromethyl- and azidomethyl-phosphonate s in good yield. This process has been used for the synthesis of diben zyl azido[H-2(2)]methylphosphonate which has been reduced and hydrogen olised to amino[H-2(2)]methylphosphonic acid under neutral conditions.