BIPHENYL ANALOGS OF NAFTIFINE - SYNTHESIS AND ANTIFUNGAL ACTIVITIES

A series of naftifine analogues having the biphenyl instead of the nap hthyl moiety have been synthesized in a search devoted to study bioana logues of clinically efficacious antifungal agents. The new derivative s were tested against Candida albicans by the direct contact method. T hey were also assayed against Gram-positive and: Gram-negative bacteri a and against some isolates of plant pathogenic fungi. Derivatives 8a, 8c, and 9a were found to be active against Candida albicans, derivati ve 5a was active against E. coli, a very resistant species to antimyco tic agents, and derivatives 8a and 8b inhibited the plant pathogenic R hizoctonia solani.