EFFECTS OF GALLOPAMIL ON EPINEPHRINE AND NOREPINEPHRINE PLASMATIC LEVELS AND ON TXB(2) AND BETA-TG RELEASE IN PATIENTS WITH CORONARY-ARTERYDISEASE DURING ADRENERGIC STIMULUS WITH COLD PRESSOR TEST

We investigated the effect of gallopamil administration during a cold presser test (CPT) in 18 patients suffering from chronic angina (CA) a nd in 21 healthy subjects. CA patients showed increased basal levels o f beta-thromboglobulin and thromboxane B-2 compared to control patient s and normal plasma levels of catecholamines. CPT caused plasma catech olamines, beta-thromboglobulin and TxB(2) levels to rise. This rise wa s greater in CA patients than in control patients. Administration of g allopamil (50 mg kg(-1) three times a day for 30 days) reduced plasma levels of catecholamines, beta-thromboglobulin and TxB(2) blood concen trations either under basal conditions or after CPT. Our data suggest that gallopamil is able to modulate the response induced by adrenergic stress. (C) 1995 The Italian Pharmacological Society